Kurzbeschreibung von: Molecular Mechanisms of Dementia. Contemporary Neuroscience

Wilma Wasco and Rudolph Tanzi bring together the best and latest thinking by leading scientists on the etiologic and pathogenic events responsible for the onset of Alzheimer's disease and related dementias. In presenting the various mechanisms and multifaceted approaches currently being employed, the distinguished contributors review such critical factors as apoptosis, energy metabolism, excitotoxicity and calcium-mediated cell death, free radicals, electrophysiological abnormalities, environmental toxins, degeneration of neural networks, and modification of the cytoskeleton. They also examine mechanisms by which ischemia and hypoxia result in dementia. The book provides critical insights into the necessary direction of future investigations of dementia.

Inhaltsverzeichnis von: Molecular Mechanisms of Dementia. Contemporary Neuroscience

Etiological Clues from Gene Defects Causing Early Onset Familial Alzheimer's Disease, Wilma Wasco and Rudolph E. Tanzi. Potential Biological Mechanisms of ApoE in Alzheimer's Disease, G.William Rebeck. Understanding the Biology and Molecular Pathogensis of Alzheimer's Disease in Transgenic Mice Expressing Amyloid Precursor Proteins, Karen K. Hsiao. Mechanism for b-Amyloid Overproduction in Alzheimer Disease: Possible Antisense RNA-Mediated Generation of a 5'-Truncated bAPP mRNA Encoding 12-kDa C-Terminal Fragment of bAPP, the Immediate Precursor of Ab, Vladimir Volloch. Apoptosis and Alzheimer's Disease, Andrea LeBlanc. The b-Amyloid Model of Alzheimer's Disease: Conformation Change, Receptor Cross-Linking, and the Initiation of Apoptosis, Carl W. Cotman, David H. Cribbs, and Aileen J. Anderson. Energy/Glucose Metabolism in Neurodegenerative Diseases, John P. Blass. Calcium Homeostasis and Free Radical Metabolism as Convergence Points in the Pathophysiology of Dementia, Mark P. Mattson, Katsutoshi Furukawa, Annadora J. Bruce, Robert J. Mark, and Emmanuelle Blanc. b-Amyloid-Derived Free Radical Oxidation: A Fundamental Process in Alzheimer's Disease, D. Allan Butterfield, Kenneth Hensley, Nathan Hall, Ramachandran Subramaniam, Beverly J. Howard, Pamela Cole, Servet Yatin, Michael LaFontaine, Marni E. Harris, Marina Aksenova, Michael Aksenov, and John M. Carney. Inflammatory Pathways: Implications in Alzheimer's Disease. Inflammatory Mediators in Alzheimer's Disease. t Protein and the Neurofibrillary Pathology of Alzheimer's Disease, Michel Goedert, John Q. Trojanowski, and Virginia M.-Y. Lee. Anatomy of Pathological Alterations in Alzheimer's Disease, Bradley T. Hyman. Cerebral Zinc Metabolism in Alzheimer's Disease, Craig S. Atwood, Robert D. Moir, Xudong Huang, Rudolp