This text attempts to refute suggestions that genetics "prove" biological determinism, arguing instead that free will itself is in the genes. It proposes that everything that makes us human can be read in our genes and considers the 21st century, when the entire human genome will be mapped out.
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During the past decade, geneticists have cloned scores of Mendelian disease genes and constructed a rough draft of the entire human genome. The unprecedented insights into human disease and evolution offered by mapping, cloning, and sequencing will transform medicine and agriculture. This revolution depends vitally on the contributions of applied mathematicians, statisticians, and computer scientists. Mathematical and Statistical Methods for ...

MARK SCHENA, Ph.D., the "Father of Microarray Technology," trained with Dan Koshland at U.C. Berkeley, Keith Yamamoto at UCSF, and Ron Davis at Stanford University. He published the first paper on microarrays in Science in 1995, and has given more than 80 lectures in 15 countries since 1995. Dr. Schena was featured as one of the Stars of Genomics on the 2001 NOVA television documentary on the Human Genome Project, and is currently a visiting ...

Wissenschaftler aus aller Welt sind am Human Genome Project beteiligt, einem Projekt zur Erfassung aller Erbinformationen, die auf den 23 Chromosomenpaaren des Menschen gespeichert sind. Dies könnte zu enormen Fortschritten in der Behandlung von Erbkrankheiten führen. Erklärt werden die Grundprinzipien der im Projekt und in der modernen Molekulargenetik verwendeten Strategien und Technologien. Ebenso werden die chemischen und ...

Erst vor kurzem wurde noch heftig über die Konsequenzen der vollständigen Entschlüsselung des menschlichen Erbguts diskutiert. Mittlerweile ist dessen Bausteinfolge fast vollständig bekannt, und wir haben uns schon daran gewöhnt, fast wöchentlich von gelungenen Gesamtsequenzierungen von Mikroorganismen, tierischen und pflanzlichen Genomen zu hören. Heute spielt die Debatte über embryonale Stammzellen und ...

Nancy Andreasen, führende Neurowissenschaftlerin, Herausgeberin des angesehenen American Journal of Psychiatry und ausgezeichnet mit der National Medal of Science, zeigt uns in ihrem neuen Buch die Zusammenhänge zwischen Gehirn und Genom. Dank modernster Methoden und Entdeckungen in Neurowissenschaften und Molekularbiologie wissen Forscher mehr denn je über die Funktionen des Gehirns. Die Autorin beschreibt auf faszinierende und ...

Sequence similarity is a powerful tool for discovering biological function. Just as the ancient Greeks used comparative anatomy to understand the human body and linguists used the Rosetta stone to decipher Egyptian hieroglyphs, today we can use comparative sequence analysis to understand genomes. BLAST (Basic Local Alignment Search Tool), is a sophisticated software package for rapid searching of nucleotide and protein databases. It is one of the ...

This book provides the basics by which researchers can approach basic and applied problems of management and enquiry of biosequence databases, as well as learn to develop computer models for the description of biological processes. This book also covers the comparative methodology involved in studying molecular evolution and reviews principles of genomics, from organization and function to a comparative description of gene structure and ...

Analysis of molecular sequence data is the main subject of this introduction to computational biology. There are two closely connected aspects to biological sequences: (i) their relative position in the space of all other sequences, and (ii) their movement through this sequence space in evolutionary time. Accordingly, the first part of the book deals with classical methods of sequence analysis: pairwise alignment, exact string matching, multiple ...

Whilst genetic transformation of plants is commonly viewed as a means of bringing about plant improvement, it has not so readily been recognised as a tool for analysing the function of plant genes. This book is unusual in that it focuses on the genetic transformation of a range of plants using a number of different methods. Many plants have been found to be quite difficult to transform, and so various techniques were developed. These techniques ...