The long-term use of glucocorticoids is associated with several deleterious effects. Attempts to separate the beneficial from the adverse effects of these compounds have met with varying degrees of difficulty. The discovery of distinct modes of action of the glucocorticoid receptor, the protein that mediates glucocorticoid action has opened up many possibilities for improving glucocorticoid therapy. This book provides an in-depth overview of the ...

Osteoporosis is indeed a global threat because every human being is vulnerable and subject to it as time goes by. The authors point out the enormous scale of the problem in terms of human suffering, morbidity and mortality on the one hand and the astronomical national costs on the other. The book is up-beat and optimistic with a touch of humour; it is scientifically based but provides easy-to-follow guidelines for lifelong maintenance of skeletal ...

In this the latest work in the Series A to Z Essentials the reader will find a comprehensive review of rheumatologic and musculoskeletal diseases together with details of recommended therapies and medication. Practitioners will thus have instant access to the information they need in their everyday work.
Rheumatologic and immunologic definitions include in-depth review of new therapeutic modalities such as cox-2 inhibitors and TNF inhibitors. ...

Thyroid Cancer describes all current diagnostic techniques, including FDG-PET and MRI. In recent years these modalities have documented hitherto hidden radioiodine-negative metastases, thus improving surgical therapy. The whole gamut of treatment, including surgery, radioiodine therapy, percutaneous radiation therapy and medical management, is covered. In some 10% of differentiated thyroid cancers, the well-known treatment tools of surgery and ...

This timely book provides basic, practical and up-to-date information on how to use imaging to diagnose and treat patients with acute ischemic stroke. Written by physicians from the Massachusetts General Hospital and faculty from the Harvard Medical School, the book distills years of experience in the day-to-day management of acute stroke patients, as well as leading-edge basic and clinical research, into a practical guide. With the growing ...

Wolf-Henning Boehncke is a scholar of the German Scholarship Foundation. His research work has been supported by continuous funding  from the German Research Foundation (DFG). He was awarded numerous prestigious prizes including the Galenus-von Pergamon Prize. Currently, he is head of the Alergy/Immunology Section at the Center for Dermatology at Frankfurt University. He is a member of numerous national and international boards involved ...

Stroke is the third leading cause of death and carotid atherosclerosis is the leading cause of embolic stroke. In recent years, the need for a more detailed analysis of atherosclerotic plaques has been stressed. Information beyond the degree of narrowing of the vessel lumen seems to be desirable and there is considerable demand for diagnostic procedures that specifically identify rupture-prone, vulnerable plaques as the most frequent cause of ...

This new title in the Springer series "A to Z Essentials"contains nearly 1000 entries on dermatologic definitions, differential diagnoses and therapeutic possibilities. The highly structured articles include succinct discussions of the signs, symptoms and therapeutic options, including designations of therapies of choice, where appropriate. The volume is richly illustrated in color and contains many tables outlining commonly used medications in ...